What are the studies?
Taueret Labs double blind gene study
Of the total 60 participants, 41% were male, 59% were female, the mean age was 35, and they were 92% Caucasian. Each participant, except for the control group, drank 4 ounces (120ml) of ASEA REDOX or placebo twice daily.
Participants' blood was drawn at week zero and at week eight. Serum RNA was extracted using a PreAnalystix PAXgene Blood RNA Kit. Gene expression levels were tested using Affymetrix PrimeView Array and differential expression within and between groups analyzed.
ASEA partnered with Taueret Laboratories, a leading genetic research laboratory, to conduct an observational study to understand how ASEA REDOX affects the activation of human genes. Taueret Labs believe in advancing medical research through leading edge genomic services. They have spearheaded projects that have led to gene testing breakthrough i multiple industries that have the potential to help countless numbers of people
The eight-week human study was reviewed and approved by Quorum Review Independent Review Board, ensuring the ethical integrity, safety, and control of the research study. The study was a randomized double blind placebo controlled study.
Researchers randomized 60 participants into three groups, 25 in the active group (ASEA REDOX), 25 in the placebo group (saline placebo), and 10 in the control group (did not drink either ASEA REDOX or placebo). It is important to note that the placebo was the same saline used to create the ASEA REDOX for this study, but did not contrain ASEA's patented redox molecules.
Results
Results of the eight-week study showed a 20 - 31% difference in gene expression abundance in five genes that are involved in pathway signaling, including regulatory network pathways. Long-term consumption of ASEA REDOX resulted in stable expression changes at the week-week time point (figure 1)
These genes are key in the health of the individual and play a vital role in the five human health areas and dozens of pathways (figure 2)
"These results are unique and exciting. ASEA REDOX is a signaling supplement and the pathways expressed are signaling genes." Dr. Kenneth Ward.
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Information is an extract from www.ASEAscience.com
Pathway Signaling
Pathway signaling genes are unique as they have the potential to influence a multitude of biological responses. Analysis of the five genes was provided through two pathway analysis programs, PANTHER (Protein ANalysis THrough Evolutionary Relationships) and WikiPathways.
Figure 3 is one gene that can influence 15 different pathways
In order to better understand how the genes reacted post-study, the ASEA REDOX group that saw the 20-31% change provided blood samples eight weeks post-study. The results demonstrated that all the changes seen while on the product had reverted back to their pre-study levels (figure 4).
The initial study data suggests that five genes expressed a change in transcription abundance.
The ASEA REDOX group saw gene activation results in regulatory pathway related genes that signal dozens of important biological function.
The ASEA REDOX and the placebo (saline) behaved differently.
There were no harmful changes in the gene expression trends of the participants consuming either beverage during the course of the study. This is representative of long-term study.
Daily consumption of ASEA REDOX over eight weeks appears to result in stable expression changes.
Changes in gene expression eight weeks post study in the ASEA REDOX group were no longer observed. This suggests continued use of ASEA REDOX is necessary to sustain the observed gene expression results.
Effects of consuming ASEA REDOX are systemic.
Effects are non-specific to race, sex or age, and were observed in all populations tested.
Summary
Information is an extract from www.ASEAscience.com
Two universities study of ASEA redox and Renu28
Key findings
internationally renowned universities have researched the impact of redox signaling molecules on different types of cells.
The research conducted independently by both universities found that the Nrf2 pathway was significantly impacted by redox signaling molecules
Nrf2 is a genetic pathway that plays a vital role in regulating genes that support response and resilience to a range of stressors. These stressors may include fatigue, emotional stress, inflammation, environmental pollution, and even lifestyle factors such as poor diet or sedentary behavior.
One key finding in the research was that supplementation with redox signaling molecules increase Nrf2 activity by up to 60%. This is significant given the Nrf2 pathway enhances the antioxidant protective system inside our bodies' cells.
Another key finding is that supplementation with redox signaling molecules increased cells' protective proteins like glutathione which play important roles in promoting overall balance. The research revealed that supplementation with redox signaling molecules increased glutathione production by 40% in healthy cells and that it restored glutathione production in compromised cells even more by -- 55%
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
University of Bath study on balancing toner
Why is it important to maintain the skin's redox balance?
Maintaining the skin redox balance is vital since the organ is constantly exposed to reactive oxygen species produced from external and internal factors
Summary
As the major organ of the body, skin is constantly striving to maintain the balance of redox homeostatis through several interconnected pathways.
The skin needs to be supplemented with nature-based ingredients to restore redox-related homeostasis when it is compromised by environmental stressors.
Chromanols, apigenin, baicalein and edelweiss are powerful plant-derived compounds for use as skin antioxidants, antiaging ingredients, and protection from sun damage.